Maria Rosa_Costanzo

Maria Rosa Costanzo MD, FHFSA

Medical Director, Midwest Cardiovascular Institute

Advanced Heart Failure and Transplant Cardiology
Midwest Cardiovascular Institute, Naperville, IL

Dr. Costanzo is currently the Medical Director of the Midwest Heart Specialists – Advocate Medical Group Heart Failure and Pulmonary Arterial Hypertension Programs, and Medical Director of the Edward Hospital Center for Advanced Heart Failure.

Dr. Costanzo graduated Summa Cum Laude from the University of Bologna Medical School, Italy and obtained her Specialty in Cardiovascular Disease from Loyola University Chicago.

Dr. Costanzo directed the Loyola University Chicago Heart Failure and Cardiac Transplant Program from 1988 until 1994 and the Rush Heart Failure and Cardiac Transplant Program from 1994 until 2001.

From 1995 until 2002 Dr. Costanzo was the John H. and Margaret V. Krehbiel Professor of Cardiology at Rush Medical College, Chicago.

Dr. Costanzo's Other Accomplishments are:

  • From 1995 until 2000 Dr. Costanzo was the Editor in Chief of the Journal of Heart and Lung Transplantation.
  • Dr. Costanzo has published nearly 200 peer-reviewed manuscripts and is the author of numerous review papers, monographs and book chapters.
  • Dr. Costanzo has chaired the preparation of the International Society of Heart and Lung Transplant Guidelines for the care of heart transplant recipients.
  • Dr. Costanzo is a Member of the AHA, ACC, ISHLT, HFSA and ESC.
  • In 2002 Dr. Costanzo was appointed by the U.S. Secretary of Health and Human Services, The Honorable Tommy Thompson to a four-year term on the National Heart and Blood Institute Advisory Council.
  • Dr. Costanzo is Member of Special Panels Convened by the National Institutes of Health to review large grants in the areas of heart failure and mechanical circulatory support.
  • Dr. Costanzo was the Principal Investigator for the Multicenter, Prospective Randomized
  • Ultrafiltration Versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure (UNLOAD) Trial published in the Journal of the American College of Cardiology in February 2007.
  • In 2010 Dr. Costanzo became Board Certified in Advanced Heart Failure and Cardiac Transplantation.
  • As of July 1, 2012, Dr. Costanzo will be a Member of the ABIM Advanced Heart Failure and Cardiac Transplantation Advisory Board. This is a committee that writes the Board Exam Questions and certifies programs wanting to have ABIM-approved fellowships in Advanced Heart Failure and Cardiac Transplantation.
  • Dr. Costanzo serves as the Principal Investigator for the Pivotal Trial of phrenic nerve stimulation for central sleep apnea, the results of which have been published in the Lancet in 2016.

Recent Publications:

  1. Tambur AR, Pamboukian SV, Costanzo MR, Herrera ND, Dunlap S, Montpetit M, Heroux A The presence of HLA-Directed Antibodies after Heart Transplantation Is Associated with Poor Allograft Outcome Transplantation 2005; 80:1019-25
  2. Pamboukian SV, Costanzo MR, Dunlap S, Rayburn B, Westfall AO, You ZY, Hung E, McLeod M, Heroux A. Relationship Between Bridging with Ventricular Assist Device on Rejection after Heart Transplantation J Heart Lung Transplant 2005; 24: 310-5
  3. Adams KF, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR et al. Characteristics and Outcomes of Patients Hospitalized for Heart Failure in the United States: Rationale, Design, and Preliminary Observations from the First 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 2005; 149:209-16.
  4. Abraham WT, Adams KF, Fonarow GC, Costanzo MR et al. In-Hospital Mortality in Patients with Acute Decompensated Heart Failure Requiring Intravenous Vasoactive Medications: an Analysis from the Acute Decompensated Heart Failure National Registry (ADHERE) J Am Coll Cardiol 2005; 46: 57-64
  5. Costanzo MR, Saltzberg M, O’Sullivan J, Sobotka P Early Ultrafiltration in Patients with Decompensated Heart Failure and Diuretic Resistance J Am Coll Cardiol 2005; 46: 2047-51
  6. Tambur AR, Pamboukian S, Costanzo MR, Heroux A Genetic Polymorphism in Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Are Significantly Associated with Cardiac Allograft Vasculopathy J Heart Lung Transplant 2006; 25: 690-98
  7. Costanzo MR, Guglin M, Saltzberg M et al. Ultrafiltration versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure. J Am Coll Cardiol 2007; 49: 675-83
  8. Fonarow GC, Shrikanthan P, Costanzo MR et al. An Obesity Paradox in Acute Heart Failure: Analysis of Body Mass Index and In hospital Mortality for 108,927 Patients in the Acute Decompensated Heart Failure National Registry. Am Heart J 2007; 153: 74-81
  9. Costanzo MR, Johannes RS, Pine M et al. The Safety of Intravenous Diuretics Alone versus Diuretics plus Parenteral Vasoactive Therapies in Hospitalized Patients with Acutely Decompensated Heart failure: A Propensity Score and Instrumental Variable Analysis Using the Acutely Decompensated Heart Failure National Registry (ADHERE) database. Am Heart J 2007; 154: 267-77
  10. Costanzo MR. Reply to “The UNLOAD Trial: A nephrologists prospective” J Am Coll Cardiol 2007; 50: 820-1
  11. Heywood, JT, Fonarow GC, Costanzo MR et al. High Prevalence of Renal Dysfunction and its Impact on Outcome of 118,465 Patients Hospitalized with Acute Decompensated Heart Failure: A Report from the ADHERE Database. J Cardiac Fail. 2007; 13: 422-30
  12. Hauptman PJ, Goodlin SJ, Lopatin M, Costanzo MR et al. Characteristics of Patients Hospitalized with Acute Decompensated Heart Failure Who Are Referred for Hospice Care. Arch Intern Med. 2007;167(18):1990-7
  13. Costanzo MR, Mills RM, Wynne JW. Characteristics of “Stage D” Heart Failure: Insights from the Acutely Decompensated Heart Failure National Registry Longitudinal Module (ADHERE LM). Am Heart Journal 2008; 155: 341-9
  14. Costanzo MR. The Role of Ultrafiltration in the Management of Heart Failure. Congest Heart Fail 2008; 14: 19-24
  15. Costanzo MR. Ultrafiltration in the Management of Heart Failure, Curr Opin Crit Care 14: 524-530
  16. Bart BA, Goldsmith SR, Boyle A, Costanzo MR. Renal Function and Ultrafiltration. J Cardiac Fail 2008; 14: 533-4
  17. Peacock WF, Costanzo MR, De Marco T et al. Impact of Intravenous Diuretics on Outcomes of Patients Hospitalized with Acute Decompensated Heart Failure: Insights from the ADHERE Registry. Cardiology 2008; 113: 12-9
  18. Bench T, Burkhoff D, O’Connell JB, Costanzo MR et al. Heart failure with Normal Ejection Fraction: Considerations of Mechanisms other than Diastolic Dysfunction. Current Heart Failure Reports 2009; 6: xx-xx
  19. Abraham WT, Burkhoff D, Nademanee K et al. FIX-HF-5 Investigators and Coordinators. A randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation in Patients with Systolic Heart Failure: Rationale, Design and Baseline Patient Characteristics. Am Heart J 2008; 156: 641-8
  20. Jessup M and Costanzo MR. The Cardiorenal Syndrome: Do We Need a Change of Strategy or a Change of tactics? J Am Coll Cardiol 2009; 53: 597-9
  21. Jessup M, Costanzo MR. Reply J Am Coll Cardiol 2009; 54: 662-3
  22. Costanzo MR, Jessup M: Renal Venous Congestion and Renal Function in Congestive Heart Failure. J Am Coll Cardiol 2009; 54: 1632-3
  23. Costanzo MR, Ponikowsi P, Javaheri S et al. Transvenous neurostimulation for central sleep apnea: a randomized controlled trial. The Lancet 2016; 388: 974-82

Appearances